Longitudinal Biochemical Assay Analysis of Mutant Huntingtin Exon 1 Protein in R6/2 Mice

BACKGROUND: Biochemical analysis of mutant huntingtin (mHTT) aggregation species in HD mice is a common measure to track disease. A longitudinal and systematic study of how tissue processing affects detection of conformers has not yet been reported. Understanding the homeostatic flux of mHTT over ti...

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Bibliografske podrobnosti
izdano v:J Huntingtons Dis
Main Authors: Morozko, Eva L., Ochaba, Joseph, Hernandez, Sarah J., Lau, Alice, Sanchez, Isabella, Orellana, Iliana, Kopan, Lexi, Crapser, Joshua, Duong, Janet H., Overman, Julia, Yeung, Silvia, Steffan, Joan S., Reidling, Jack, Thompson, Leslie M.
Format: Artigo
Jezik:Inglês
Izdano: IOS Press 2018
Teme:
Research Report
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6294605/
https://ncbi.nlm.nih.gov/pubmed/30452420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JHD-180329
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