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Several structural motifs cooperate in determining the highly effective anti-thrombin activity of NU172 aptamer
Despite aptamers are very promising alternative to antibodies, very few of them are under clinical trials or are used as drugs. Among them, NU172 is currently in Phase II as anticoagulant in heart disease treatments. It inhibits thrombin activity much more effectively than TBA, the best-known thromb...
Enregistré dans:
| Publié dans: | Nucleic Acids Res |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6294562/ https://ncbi.nlm.nih.gov/pubmed/30357392 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky990 |
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