ErbB2-driven downregulation of the transcription factor Irf6 in breast epithelial cells is required for their 3D growth

BACKGROUND: The ability of solid tumor cells to resist anoikis, apoptosis triggered by cell detachment from the extracellular matrix (ECM), is thought to be critical for 3D tumor growth. ErbB2/Her2 oncoprotein is often overproduced by breast tumor cells and blocks their anoikis by partially understo...

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Bibliografske podrobnosti
izdano v:Breast Cancer Res
Main Authors: Khan, Iman Aftab, Yoo, Byong Hoon, McPhee, Michael, Masson, Olivier, Surette, Alexi, Dakin-Hache, Kelly, Younis, Tallal, Bethune, Gillian, Rosen, Kirill V.
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2018
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6293553/
https://ncbi.nlm.nih.gov/pubmed/30545388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-018-1080-1
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