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Endocytic downregulation of ErbB receptors: mechanisms and relevance in cancer
ErbB receptors (EGFR (ErbB1), ErbB2, ErbB3, and ErbB4) are important regulators of normal growth and differentiation, and they are involved in the pathogenesis of cancer. Following ligand binding and receptor activation, EGFR is endocytosed and transported to lysosomes where the receptor is degraded...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer-Verlag
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2323030/ https://ncbi.nlm.nih.gov/pubmed/18288481 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00418-008-0401-3 |
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