Differential Effects of EGFR Ligands on Endocytic Sorting of the Receptor

Endocytic downregulation is a pivotal mechanism turning off signalling from the EGF receptor (EGFR). It is well established that whereas EGF binding leads to lysosomal degradation of EGFR, transforming growth factor (TGF)-α causes receptor recycling. TGF-α therefore leads to continuous signalling an...

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Autors principals: Roepstorff, Kirstine, Grandal, Michael Vibo, Henriksen, Lasse, Knudsen, Stine Louise Jeppe, Lerdrup, Mads, Grøvdal, Lene, Willumsen, Berthe Marie, van Deurs, Bo
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2009
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2723868/
https://ncbi.nlm.nih.gov/pubmed/19531065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-0854.2009.00943.x
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