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Endocytic Down-Regulation of ErbB2 Is Stimulated by Cleavage of Its C-Terminus

High ErbB2 levels are associated with cancer, and impaired endocytosis of ErbB2 could contribute to its overexpression. Therefore, knowledge about the mechanisms underlying endocytic down-regulation of ErbB2 is warranted. The C-terminus of ErbB2 can be cleaved after various stimuli, and after inhibi...

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Detalhes bibliográficos
Main Authors: Lerdrup, Mads, Bruun, Silas, Grandal, Michael V., Roepstorff, Kirstine, Kristensen, Malene M., Hommelgaard, Anette M., van Deurs, Bo
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1951740/
https://ncbi.nlm.nih.gov/pubmed/17626164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E07-01-0025
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