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Endocytic Down-Regulation of ErbB2 Is Stimulated by Cleavage of Its C-Terminus
High ErbB2 levels are associated with cancer, and impaired endocytosis of ErbB2 could contribute to its overexpression. Therefore, knowledge about the mechanisms underlying endocytic down-regulation of ErbB2 is warranted. The C-terminus of ErbB2 can be cleaved after various stimuli, and after inhibi...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The American Society for Cell Biology
2007
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1951740/ https://ncbi.nlm.nih.gov/pubmed/17626164 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E07-01-0025 |
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