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Differential Effects of EGFR Ligands on Endocytic Sorting of the Receptor
Endocytic downregulation is a pivotal mechanism turning off signalling from the EGF receptor (EGFR). It is well established that whereas EGF binding leads to lysosomal degradation of EGFR, transforming growth factor (TGF)-α causes receptor recycling. TGF-α therefore leads to continuous signalling an...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Blackwell Publishing Ltd
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2723868/ https://ncbi.nlm.nih.gov/pubmed/19531065 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-0854.2009.00943.x |
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