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Pulsatile hyperglycemia increases insulin secretion but not pancreatic β-cell mass in intrauterine growth-restricted fetal sheep

Impaired β-cell development and insulin secretion are characteristic of intrauterine growth-restricted (IUGR) fetuses. In normally grown late gestation fetal sheep pancreatic β-cell numbers and insulin secretion are increased by 7–10 days of pulsatile hyperglycemia (PHG). Our objective was to determ...

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書誌詳細
出版年:J Dev Orig Health Dis
主要な著者: Boehmer, B. H., Brown, L. D., Wesolowski, S. R., Hay, W. W., Rozance, P. J.
フォーマット: Artigo
言語:Inglês
出版事項: 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6293458/
https://ncbi.nlm.nih.gov/pubmed/29973299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/S2040174418000417
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