MDM2 inhibitor ameliorates cisplatin‐induced nephropathy via NFκΒ signal inhibition

Cisplatin is a platinum‐containing chemotherapeutic drug, which is widely used and highly effective. While effective against tumors, its use is limited by severe side effects such as nephrotoxicity and bone marrow suppression. Murine double minute 2 (MDM2) is the E3 ubiquitin ligase of the tumor sup...

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Dettagli Bibliografici
Pubblicato in:Pharmacol Res Perspect
Autori principali: Fujikura, Tomoyuki, Yasuda, Hideo, Iwakura, Takamasa, Tsuji, Takayuki, Anders, Hans‐J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2018
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6293176/
https://ncbi.nlm.nih.gov/pubmed/30564368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.450
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