A transient DMSO treatment increases the differentiation potential of human pluripotent stem cells through the Rb family

The propensity for differentiation varies substantially across human pluripotent stem cell (hPSC) lines, greatly restricting the use of hPSCs for cell replacement therapy or disease modeling. Here, we investigate the underlying mechanisms and demonstrate that activation of the retinoblastoma (Rb) pa...

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Bibliographic Details
Published in:PLoS One
Main Authors: Li, Jingling, Narayanan, Cyndhavi, Bian, Jing, Sambo, Danielle, Brickler, Thomas, Zhang, Wancong, Chetty, Sundari
Format: Artigo
Language:Inglês
Published: Public Library of Science 2018
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6291069/
https://ncbi.nlm.nih.gov/pubmed/30540809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0208110
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