A transient DMSO treatment increases the differentiation potential of human pluripotent stem cells through the Rb family

The propensity for differentiation varies substantially across human pluripotent stem cell (hPSC) lines, greatly restricting the use of hPSCs for cell replacement therapy or disease modeling. Here, we investigate the underlying mechanisms and demonstrate that activation of the retinoblastoma (Rb) pa...

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Dades bibliogràfiques
Publicat a:PLoS One
Autors principals: Li, Jingling, Narayanan, Cyndhavi, Bian, Jing, Sambo, Danielle, Brickler, Thomas, Zhang, Wancong, Chetty, Sundari
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6291069/
https://ncbi.nlm.nih.gov/pubmed/30540809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0208110
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