Therapeutic Targeting of Vascular Remodeling and Right Heart Failure in Pulmonary Arterial Hypertension with a HIF-2α Inhibitor

Rationale: Pulmonary arterial hypertension (PAH) is a devastating disease characterized by progressive vasoconstriction and obliterative vascular remodeling that leads to right heart failure (RHF) and death. Current therapies do not target vascular remodeling and RHF, and result in only modest impro...

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Publicado en:Am J Respir Crit Care Med
Autores principales: Dai, Zhiyu, Zhu, Maggie M., Peng, Yi, Machireddy, Narsa, Evans, Colin E., Machado, Roberto, Zhang, Xianming, Zhao, You-Yang
Formato: Artigo
Lenguaje:Inglês
Publicado: American Thoracic Society 2018
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6290950/
https://ncbi.nlm.nih.gov/pubmed/29924941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201710-2079OC
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