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Therapeutic Targeting of Vascular Remodeling and Right Heart Failure in Pulmonary Arterial Hypertension with a HIF-2α Inhibitor

Rationale: Pulmonary arterial hypertension (PAH) is a devastating disease characterized by progressive vasoconstriction and obliterative vascular remodeling that leads to right heart failure (RHF) and death. Current therapies do not target vascular remodeling and RHF, and result in only modest impro...

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Detalhes bibliográficos
Publicado no:Am J Respir Crit Care Med
Main Authors: Dai, Zhiyu, Zhu, Maggie M., Peng, Yi, Machireddy, Narsa, Evans, Colin E., Machado, Roberto, Zhang, Xianming, Zhao, You-Yang
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6290950/
https://ncbi.nlm.nih.gov/pubmed/29924941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201710-2079OC
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