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GCN2 kinase activation mediates pulmonary vascular remodeling and pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is characterized by progressive increase of pulmonary vascular resistance and remodeling that result in right heart failure. Recessive mutations of EIF2AK4 gene (encoding general control nonderepressible 2 kinase, GCN2) are linked to heritable pulmonary veno-occ...
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| Hoofdauteurs: | , , , , |
|---|---|
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Society for Clinical investigation
2024-10-01
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| Reeks: | JCI Insight |
| Onderwerpen: | |
| Online toegang: | https://doi.org/10.1172/jci.insight.177926 |
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