GCN2 kinase activation mediates pulmonary vascular remodeling and pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) is characterized by progressive increase of pulmonary vascular resistance and remodeling that result in right heart failure. Recessive mutations of EIF2AK4 gene (encoding general control nonderepressible 2 kinase, GCN2) are linked to heritable pulmonary veno-occ...

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Main Authors: Maggie M. Zhu, Jingbo Dai, Zhiyu Dai, Yi Peng, You-Yang Zhao
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical investigation 2024-10-01
Series:JCI Insight
Assuntos:
Vascular biology
Acceso en liña:https://doi.org/10.1172/jci.insight.177926
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