Therapeutic Targeting of Vascular Remodeling and Right Heart Failure in Pulmonary Arterial Hypertension with a HIF-2α Inhibitor

Rationale: Pulmonary arterial hypertension (PAH) is a devastating disease characterized by progressive vasoconstriction and obliterative vascular remodeling that leads to right heart failure (RHF) and death. Current therapies do not target vascular remodeling and RHF, and result in only modest impro...

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Bibliografiske detaljer
Udgivet i:Am J Respir Crit Care Med
Main Authors: Dai, Zhiyu, Zhu, Maggie M., Peng, Yi, Machireddy, Narsa, Evans, Colin E., Machado, Roberto, Zhang, Xianming, Zhao, You-Yang
Format: Artigo
Sprog:Inglês
Udgivet: American Thoracic Society 2018
Fag:
Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6290950/
https://ncbi.nlm.nih.gov/pubmed/29924941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201710-2079OC
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