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Pan-PIM Kinase Inhibitors Enhance Lenalidomide’s Anti-myeloma Activity Via Cereblon-IKZF1/3 Cascade
Multiple myeloma remains an incurable disease, and continued efforts are required to develop novel agents and novel drug combinations with more effective anti-myeloma activity. Here, we show that the pan-PIM kinase inhibitors SGI1776 and CX6258 exhibit significant anti-myeloma activity and that comb...
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| Publicat a: | Cancer Lett |
|---|---|
| Autors principals: | , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6290736/ https://ncbi.nlm.nih.gov/pubmed/30312729 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2018.10.003 |
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