Pan-PIM Kinase Inhibitors Enhance Lenalidomide’s Anti-myeloma Activity Via Cereblon-IKZF1/3 Cascade

Multiple myeloma remains an incurable disease, and continued efforts are required to develop novel agents and novel drug combinations with more effective anti-myeloma activity. Here, we show that the pan-PIM kinase inhibitors SGI1776 and CX6258 exhibit significant anti-myeloma activity and that comb...

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Pubblicato in:Cancer Lett
Autori principali: Zheng, Jing, Sha, Yonggang, Roof, Logan, Foreman, Oded, Lazarchick, John, Venkta, Jagadish Kummetha, Kozlowski, Cleopatra, Gasparetto, Cristina, Chao, Nelson, Ebens, Allen, Hu, Jianda, Kang, Yubin
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6290736/
https://ncbi.nlm.nih.gov/pubmed/30312729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2018.10.003
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