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The kinases IKBKE and TBK1 regulate MYC-dependent survival pathways through YB-1 in AML and are targets for therapy

To identify novel therapeutic targets in acute myeloid leukemia (AML), we examined kinase expression patterns in primary AML samples. We found that the serine/threonine kinase IKBKE, a noncanonical IkB kinase, is expressed at higher levels in myeloid leukemia cells compared with normal hematopoietic...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Liu, Suhu, Marneth, Anna E., Alexe, Gabriela, Walker, Sarah R., Gandler, Helen I., Ye, Darwin Q., Labella, Katherine, Mathur, Radhika, Toniolo, Patricia A., Tillgren, Michelle, Gokhale, Prafulla C., Barbie, David, Mullally, Ann, Stegmaier, Kimberly, Frank, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6290107/
https://ncbi.nlm.nih.gov/pubmed/30504235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018016733
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