Oral Coadministration of Fluconazole with Tramadol Markedly Increases Plasma and Urine Concentrations of Tramadol and the O-Desmethyltramadol Metabolite in Healthy Dogs

Tramadol is used frequently in the management of mild to moderate pain conditions in dogs. This use is controversial because multiple reports in treated dogs demonstrate very low plasma concentrations of O-desmethyltramadol (M1), the active metabolite. The objective of this study was to identify a d...

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Bibliographic Details
Published in:Drug Metab Dispos
Main Authors: Perez Jimenez, Tania E., Kukanich, Butch, Joo, Hyun, Mealey, Katrina L., Grubb, Tamara L., Greene, Stephen A., Court, Michael H.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6290082/
https://ncbi.nlm.nih.gov/pubmed/30366901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.118.083444
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