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Effects of the central analgesic tramadol and its main metabolite, O-desmethyltramadol, on rat locus coeruleus neurones.

1. Tramadol is a centrally acting analgesic with low opioid receptor affinity and, therefore, presumably additional mechanisms of analgesic action. Tramadol and its main metabolite O-desmethyltramadol were tested on rat central noradrenergic neurones of the nucleus locus coeruleus (LC), which are in...

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Библиографические подробности
Главные авторы: Sevcik, J., Nieber, K., Driessen, B., Illes, P.
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 1993
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2175982/
https://ncbi.nlm.nih.gov/pubmed/8220877
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