Identification of canine cytochrome P-450s (CYPs) metabolizing the tramadol (+)-M1 and (+)-M2 metabolites to the tramadol (+)-M5 metabolite in dog liver microsomes

We previously showed that (+)-tramadol is metabolized in dog liver to (+)-M1 exclusively by CYP2D15 and to (+)-M2 by multiple CYPs, but primarily CYP2B11. However, (+)-M1 and (+)-M2 are further metabolized in dogs to (+)-M5, which is the major metabolite found in dog plasma and urine. In this study...

Full description

Saved in:
Bibliographic Details
Published in:J Vet Pharmacol Ther
Main Authors: Perez Jimenez, Tania E., Mealey, Katrina L., Schnider, Darren, Grubb, Tamara L., Greene, Stephen A., Court, Michael H.
Format: Artigo
Language:Inglês
Published: 2018
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6214715/
https://ncbi.nlm.nih.gov/pubmed/30113702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jvp.12706
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items