Загрузка...
Identification of canine cytochrome P-450s (CYPs) metabolizing the tramadol (+)-M1 and (+)-M2 metabolites to the tramadol (+)-M5 metabolite in dog liver microsomes
We previously showed that (+)-tramadol is metabolized in dog liver to (+)-M1 exclusively by CYP2D15 and to (+)-M2 by multiple CYPs, but primarily CYP2B11. However, (+)-M1 and (+)-M2 are further metabolized in dogs to (+)-M5, which is the major metabolite found in dog plasma and urine. In this study...
Сохранить в:
| Опубликовано в: : | J Vet Pharmacol Ther |
|---|---|
| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2018
|
| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6214715/ https://ncbi.nlm.nih.gov/pubmed/30113702 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jvp.12706 |
| Метки: |
Добавить метку
Нет меток, Требуется 1-ая метка записи!
|