Escin-induced DNA damage promotes escin-induced apoptosis in human colorectal cancer cells via p62 regulation of the ATM/γH2AX pathway

Escin, a triterpene saponin isolated from horse chestnut seed, has been used to treat encephaledema, tissue swelling and chronic venous insufficiency. Recent studies show that escin induces cell cycle arrest, tumor proliferation inhibition and tumor cell apoptosis. But the relationship between escin...

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Dettagli Bibliografici
Pubblicato in:Acta Pharmacol Sin
Autori principali: Wang, Zhong, Chen, Qiang, Li, Bin, Xie, Jia-ming, Yang, Xiao-dong, Zhao, Kui, Wu, Yong, Ye, Zhen-yu, Chen, Zheng-rong, Qin, Zheng-hong, Xing, Chun-gen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6289333/
https://ncbi.nlm.nih.gov/pubmed/29849127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2017.192
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