The HINT1 tumor suppressor regulates both γ-H2AX and ATM in response to DNA damage

Hint1 is a haploinsufficient tumor suppressor gene and the underlying molecular mechanisms for its tumor suppressor function are unknown. In this study we demonstrate that HINT1 participates in ionizing radiation (IR)–induced DNA damage responses. In response to IR, HINT1 is recruited to IR-induced...

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Sonraí Bibleagrafaíochta
Main Authors: Li, Haiyang, Balajee, Adayabalam S., Su, Tao, Cen, Bo, Hei, Tom K., Weinstein, I. Bernard
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Rockefeller University Press 2008
Ábhair:
Research Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2568022/
https://ncbi.nlm.nih.gov/pubmed/18852295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200711150
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