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The HINT1 tumor suppressor regulates both γ-H2AX and ATM in response to DNA damage

Hint1 is a haploinsufficient tumor suppressor gene and the underlying molecular mechanisms for its tumor suppressor function are unknown. In this study we demonstrate that HINT1 participates in ionizing radiation (IR)–induced DNA damage responses. In response to IR, HINT1 is recruited to IR-induced...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Li, Haiyang, Balajee, Adayabalam S., Su, Tao, Cen, Bo, Hei, Tom K., Weinstein, I. Bernard
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Rockefeller University Press 2008
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2568022/
https://ncbi.nlm.nih.gov/pubmed/18852295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200711150
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