Chk2 Is a Tumor Suppressor That Regulates Apoptosis in both an Ataxia Telangiectasia Mutated (ATM)-Dependent and an ATM-Independent Manner

In response to ionizing radiation (IR), the tumor suppressor p53 is stabilized and promotes either cell cycle arrest or apoptosis. Chk2 activated by IR contributes to this stabilization, possibly by direct phosphorylation. Like p53, Chk2 is mutated in patients with Li-Fraumeni syndrome. Since the at...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Hirao, Atsushi, Cheung, Alison, Duncan, Gordon, Girard, Pierre-Marie, Elia, Andrew J., Wakeham, Andrew, Okada, Hitoshi, Sarkissian, Talin, Wong, Jorge A., Sakai, Takashi, de Stanchina, Elisa, Bristow, Robert G., Suda, Toshio, Lowe, Scott W., Jeggo, Penny A., Elledge, Stephen J., Mak, Tak W.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2002
Assuntos:	Cell Growth and Development
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC135625/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12192050/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.18.6521-6532.2002
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