Chk2 Is a Tumor Suppressor That Regulates Apoptosis in both an Ataxia Telangiectasia Mutated (ATM)-Dependent and an ATM-Independent Manner

In response to ionizing radiation (IR), the tumor suppressor p53 is stabilized and promotes either cell cycle arrest or apoptosis. Chk2 activated by IR contributes to this stabilization, possibly by direct phosphorylation. Like p53, Chk2 is mutated in patients with Li-Fraumeni syndrome. Since the at...

Täydet tiedot

Bibliografiset tiedot

Julkaisussa:	Mol Cell Biol
Päätekijät:	Hirao, Atsushi, Cheung, Alison, Duncan, Gordon, Girard, Pierre-Marie, Elia, Andrew J., Wakeham, Andrew, Okada, Hitoshi, Sarkissian, Talin, Wong, Jorge A., Sakai, Takashi, de Stanchina, Elisa, Bristow, Robert G., Suda, Toshio, Lowe, Scott W., Jeggo, Penny A., Elledge, Stephen J., Mak, Tak W.
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Taylor & Francis 2002
Aiheet:	Cell Growth and Development
Linkit:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC135625/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12192050/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.18.6521-6532.2002
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