Chk2 Is a Tumor Suppressor That Regulates Apoptosis in both an Ataxia Telangiectasia Mutated (ATM)-Dependent and an ATM-Independent Manner

In response to ionizing radiation (IR), the tumor suppressor p53 is stabilized and promotes either cell cycle arrest or apoptosis. Chk2 activated by IR contributes to this stabilization, possibly by direct phosphorylation. Like p53, Chk2 is mutated in patients with Li-Fraumeni syndrome. Since the at...

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Detalles Bibliográficos

Publicado en:	Mol Cell Biol
Principais autores:	Hirao, Atsushi, Cheung, Alison, Duncan, Gordon, Girard, Pierre-Marie, Elia, Andrew J., Wakeham, Andrew, Okada, Hitoshi, Sarkissian, Talin, Wong, Jorge A., Sakai, Takashi, de Stanchina, Elisa, Bristow, Robert G., Suda, Toshio, Lowe, Scott W., Jeggo, Penny A., Elledge, Stephen J., Mak, Tak W.
Formato:	Artigo
Idioma:	Inglês
Publicado:	Taylor & Francis 2002
Assuntos:	Cell Growth and Development
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC135625/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12192050/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.18.6521-6532.2002
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