Imaging DNA damage in vivo using γH2AX-targeted immunoconjugates

DNA damage responses (DDRs) occur during oncogenesis and therapeutic responses to DNA damaging cytotoxic drugs. Thus, a real-time method to image DNA damage in vivo would be useful to diagnose cancer and monitor its treatment. Toward this end, we have developed fluorophore- and radioisotope-labeled...

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Detalhes bibliográficos
Main Authors: Cornelissen, Bart, Kersemans, Veerle, Darbar, Sonali, Thompson, James, Shah, Ketan, Sleeth, Kate, Hill, Mark A., Vallis, Katherine A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3130133/
https://ncbi.nlm.nih.gov/pubmed/21586614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-4587
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