KRAS(G12D)-mediated oncogenic transformation of thyroid follicular cells requires long-term TSH stimulation and is regulated by SPRY1

KRAS(G12D) can cause lung cancer rapidly, but is not sufficient to induce thyroid cancer. It is not clear whether long-term serum thyroid stimulating hormone (TSH) stimulation can promote KRAS(G12D)-mediated thyroid follicular cell transformation. In the present study, we investigated the effect of...

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Veröffentlicht in:Lab Invest
Hauptverfasser: Zou, Minjing, Baitei, Essa Y, Al-Rijjal, Roua A, Parhar, Ranjit S, Al-Mohanna, Futwan A, Kimura, Shioko, Pritchard, Catrin, BinEssa, Huda, Alanazi, Azizah A, Alzahrani, Ali S, Akhtar, Mohammed, Assiri, Abdullah M, Meyer, Brian F, Shi, Yufei
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6289253/
https://ncbi.nlm.nih.gov/pubmed/26146959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.2015.90
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