Cyp24a1 Attenuation Limits Progression of Braf(V600E)-Induced Papillary Thyroid Cancer Cells and Sensitizes Them to BRAF(V600E) Inhibitor PLX4720

CYP24A1, the primary inactivating enzyme for vitamin D, is often overexpressed in human cancers, potentially neutralizing the antitumor effects of calcitriol, the active form of vitamin D. However, it is unclear whether CYP24A1 expression serves as a functional contributor versus only a biomarker fo...

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Bibliografiset tiedot
Julkaisussa:Cancer Res
Päätekijät: Zou, Minjing, Baitei, Essa Y., BinEssa, Huda A., Al-Mohanna, Futwan A., Parhar, Ranjit S., St-Arnaud, Rene′, Kimura, Shioko, Pritchard, Catrin, Alzahrani, Ali S., Assiri, Abdullah M., Meyer, Brian F., Shi, Yufei
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2017
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6317881/
https://ncbi.nlm.nih.gov/pubmed/28242615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-2066
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