TSH overcomes Braf(V600E)-induced senescence to promote tumor progression via downregulation of p53 expression in papillary thyroid cancer

The BRAF(V600E) mutation is found in approximately 40% of papillary thyroid cancers (PTC). Mice with thyroid-specific expression of Braf(V600E) (TPO–Braf(V600E)) develop PTC rapidly with high levels of serum thyroid-stimulating hormone (TSH). It is unclear to what extent the elevated TSH contributes...

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Foilsithe in:Oncogene
Main Authors: Zou, M, Baitei, EY, AI-Rijjal, RA, Parhar, RS, Al-Mohanna, FA, Kimura, S, Pritchard, C, Binessa, HA, Alzahrani, AS, Al-Khalaf, HH, Hawwari, A, Akhtar, M, Assiri, AM, Meyer, BF, Shi, Y
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2015
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6310059/
https://ncbi.nlm.nih.gov/pubmed/26477313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.253
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