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Identification of Antinorovirus Genes in Human Cells Using Genome-Wide CRISPR Activation Screening

Noroviruses (NoVs) are a leading cause of gastroenteritis worldwide, yet host factors that restrict NoV replication are not well understood. Here, we use a CRISPR activation genome-wide screening to identify host genes that can inhibit murine norovirus (MNoV) replication in human cells. Our screens...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Orchard, Robert C., Sullender, Meagan E., Dunlap, Bria F., Balce, Dale R., Doench, John G., Virgin, Herbert W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6288323/
https://ncbi.nlm.nih.gov/pubmed/30305350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01324-18
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