Two Interlinked Bistable Switches Govern Mitotic Control in Mammalian Cells

Distinct protein phosphorylation levels in interphase and M phase require tight regulation of Cdk1 activity [1, 2]. A bistable switch, based on positive feedback in the Cdk1 activation loop, has been proposed to generate different thresholds for transitions between these cell-cycle states [3, 4, 5]....

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Pubblicato in:Curr Biol
Autori principali: Rata, Scott, Suarez Peredo Rodriguez, Maria F., Joseph, Stephy, Peter, Nisha, Echegaray Iturra, Fabio, Yang, Fengwei, Madzvamuse, Anotida, Ruppert, Jan G., Samejima, Kumiko, Platani, Melpomeni, Alvarez-Fernandez, Monica, Malumbres, Marcos, Earnshaw, William C., Novak, Bela, Hochegger, Helfrid
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6287978/
https://ncbi.nlm.nih.gov/pubmed/30449668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2018.09.059
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