PP2A/B55 and Fcp1 Regulate Greatwall and Ensa Dephosphorylation during Mitotic Exit

Entry into mitosis is triggered by activation of Cdk1 and inactivation of its counteracting phosphatase PP2A/B55. Greatwall kinase inactivates PP2A/B55 via its substrates Ensa and ARPP19. Both Greatwall and Ensa/ARPP19 are regulated by phosphorylation, but the dynamic regulation of Greatwall activit...

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Bibliographic Details
Main Authors: Hégarat, Nadia, Vesely, Clare, Vinod, P. K., Ocasio, Cory, Peter, Nisha, Gannon, Julian, Oliver, Antony W., Novák, Béla, Hochegger, Helfrid
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3879168/
https://ncbi.nlm.nih.gov/pubmed/24391510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004004
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