A Lamina-Associated Domain Border Governs Nuclear Lamina Interactions, Transcription, and Recombination of the Tcrb Locus

Tcrb locus V(D)J recombination is regulated by positioning at the nuclear periphery. Here, we used DamID to profile Tcrb locus interactions with the nuclear lamina at high resolution. We identified a lamina-associated domain (LAD) border composed of several CTCF-binding elements that segregates acti...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Rep
Prif Awduron: Chen, Shiwei, Luperchio, Teresa Romeo, Wong, Xianrong, Doan, Europe B., Byrd, Aaron T., Choudhury, Kingshuk Roy, Reddy, Karen L., Krangel, Michael S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6287930/
https://ncbi.nlm.nih.gov/pubmed/30428344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.10.052
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