A Lamina-Associated Domain Border Governs Nuclear Lamina Interactions, Transcription, and Recombination of the Tcrb Locus

Tcrb locus V(D)J recombination is regulated by positioning at the nuclear periphery. Here, we used DamID to profile Tcrb locus interactions with the nuclear lamina at high resolution. We identified a lamina-associated domain (LAD) border composed of several CTCF-binding elements that segregates acti...

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Bibliografske podrobnosti
izdano v:Cell Rep
Main Authors: Chen, Shiwei, Luperchio, Teresa Romeo, Wong, Xianrong, Doan, Europe B., Byrd, Aaron T., Choudhury, Kingshuk Roy, Reddy, Karen L., Krangel, Michael S.
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6287930/
https://ncbi.nlm.nih.gov/pubmed/30428344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.10.052
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