Nucleosome positions establish an extended mutation signature in melanoma

Ultraviolet (UV) light-induced mutations are unevenly distributed across skin cancer genomes, but the molecular mechanisms responsible for this heterogeneity are not fully understood. Here, we assessed how nucleosome structure impacts the positions of UV-induced mutations in human melanomas. Analysi...

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Gepubliceerd in:PLoS Genet
Hoofdauteurs: Brown, Alexander J., Mao, Peng, Smerdon, Michael J., Wyrick, John J., Roberts, Steven A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2018
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6287878/
https://ncbi.nlm.nih.gov/pubmed/30485262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007823
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