Nucleosome positions establish an extended mutation signature in melanoma

Ultraviolet (UV) light-induced mutations are unevenly distributed across skin cancer genomes, but the molecular mechanisms responsible for this heterogeneity are not fully understood. Here, we assessed how nucleosome structure impacts the positions of UV-induced mutations in human melanomas. Analysi...

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Detaylı Bibliyografya
Yayımlandı:PLoS Genet
Asıl Yazarlar: Brown, Alexander J., Mao, Peng, Smerdon, Michael J., Wyrick, John J., Roberts, Steven A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2018
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6287878/
https://ncbi.nlm.nih.gov/pubmed/30485262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007823
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