Virotherapy-recruited PMN-MDSC infiltration of mesothelioma blocks antitumor CTL by IL-10-mediated dendritic cell suppression

Antitumor cytotoxic T lymphocytes (CTLs) are essential for immune surveillance, yet the blockade of eliciting such CTLs during oncolytic virotherapy remains incompletely understood. Here, we show that oncolysis of mesothelioma by modified vaccinia Tiantan (MVTT) induces damage-associated molecular p...

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Vydáno v:Oncoimmunology
Hlavní autoři: Tan, Zhiwu, Liu, Li, Chiu, Mei Sum, Cheung, Ka-Wai, Yan, Chi Wing, Yu, Zhe, Lee, Boon Kiat, Liu, Wan, Man, Kwan, Chen, Zhiwei
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2018
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6287797/
https://ncbi.nlm.nih.gov/pubmed/30546960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2018.1518672
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