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Eliminating mesothelioma by AAV-vectored, PD1-based vaccination in the tumor microenvironment

The potency of cancer vaccines is often compromised by a variety of immunoinhibitory mechanisms, including stimulation of the programmed cell death protein 1 (PD-1)/programmed death ligand 1 (PD-L1) immune checkpoint pathway. Here, to overcome inhibition, we determined the potential of recombinant a...

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Detalhes bibliográficos
Publicado no:Mol Ther Oncolytics
Main Authors: Tan, Zhiwu, Chiu, Mei Sum, Yan, Chi Wing, Man, Kwan, Chen, Zhiwei
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7878991/
https://ncbi.nlm.nih.gov/pubmed/33614918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omto.2021.01.010
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