Virotherapy-recruited PMN-MDSC infiltration of mesothelioma blocks antitumor CTL by IL-10-mediated dendritic cell suppression

Antitumor cytotoxic T lymphocytes (CTLs) are essential for immune surveillance, yet the blockade of eliciting such CTLs during oncolytic virotherapy remains incompletely understood. Here, we show that oncolysis of mesothelioma by modified vaccinia Tiantan (MVTT) induces damage-associated molecular p...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncoimmunology
Auteurs principaux: Tan, Zhiwu, Liu, Li, Chiu, Mei Sum, Cheung, Ka-Wai, Yan, Chi Wing, Yu, Zhe, Lee, Boon Kiat, Liu, Wan, Man, Kwan, Chen, Zhiwei
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2018
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6287797/
https://ncbi.nlm.nih.gov/pubmed/30546960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2018.1518672
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