Virotherapy-recruited PMN-MDSC infiltration of mesothelioma blocks antitumor CTL by IL-10-mediated dendritic cell suppression

Antitumor cytotoxic T lymphocytes (CTLs) are essential for immune surveillance, yet the blockade of eliciting such CTLs during oncolytic virotherapy remains incompletely understood. Here, we show that oncolysis of mesothelioma by modified vaccinia Tiantan (MVTT) induces damage-associated molecular p...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Tan, Zhiwu, Liu, Li, Chiu, Mei Sum, Cheung, Ka-Wai, Yan, Chi Wing, Yu, Zhe, Lee, Boon Kiat, Liu, Wan, Man, Kwan, Chen, Zhiwei
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6287797/
https://ncbi.nlm.nih.gov/pubmed/30546960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2018.1518672
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