Virotherapy-recruited PMN-MDSC infiltration of mesothelioma blocks antitumor CTL by IL-10-mediated dendritic cell suppression

Antitumor cytotoxic T lymphocytes (CTLs) are essential for immune surveillance, yet the blockade of eliciting such CTLs during oncolytic virotherapy remains incompletely understood. Here, we show that oncolysis of mesothelioma by modified vaccinia Tiantan (MVTT) induces damage-associated molecular p...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Oncoimmunology
Prif Awduron: Tan, Zhiwu, Liu, Li, Chiu, Mei Sum, Cheung, Ka-Wai, Yan, Chi Wing, Yu, Zhe, Lee, Boon Kiat, Liu, Wan, Man, Kwan, Chen, Zhiwei
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Taylor & Francis 2018
Pynciau:
Original Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6287797/
https://ncbi.nlm.nih.gov/pubmed/30546960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2018.1518672
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