HER2 signaling regulates the tumor immune microenvironment and trastuzumab efficacy

Through whole-transcriptome profiling of HER2+ breast carcinomas (BCs), we previously showed that those sensitive to trastuzumab are addicted to this oncoprotein and are enriched in immune pathways, raising the hypothesis that HER2 itself regulates immune cell recruitment. In the present study we in...

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Bibliographische Detailangaben
Veröffentlicht in:Oncoimmunology
Hauptverfasser: Triulzi, Tiziana, Forte, Luca, Regondi, Viola, Di Modica, Martina, Ghirelli, Cristina, Carcangiu, Maria Luisa, Sfondrini, Lucia, Balsari, Andrea, Tagliabue, Elda
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2018
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6287794/
https://ncbi.nlm.nih.gov/pubmed/30546951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2018.1512942
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