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Synthesis of small peptide compounds, molecular docking, and inhibitory activity evaluation against phosphatases PTP1B and SHP2

BACKGROUND: The protein tyrosine phosphatases PTP1B and SHP2 are promising drug targets in treatment design for breast cancer. Searching for specific inhibitors of their activity has recently become the challenge of many studies. Previous work has indicated that the promising PTP inhibitors may be s...

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Bibliografske podrobnosti
izdano v:Drug Des Devel Ther
Main Authors: Kostrzewa, Tomasz, Sahu, Kamlesh K, Gorska-Ponikowska, Magdalena, Tuszynski, Jack A, Kuban-Jankowska, Alicja
Format: Artigo
Jezik:Inglês
Izdano: Dove Medical Press 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6287413/
https://ncbi.nlm.nih.gov/pubmed/30584278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S186614
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