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Synthesis of small peptide compounds, molecular docking, and inhibitory activity evaluation against phosphatases PTP1B and SHP2

BACKGROUND: The protein tyrosine phosphatases PTP1B and SHP2 are promising drug targets in treatment design for breast cancer. Searching for specific inhibitors of their activity has recently become the challenge of many studies. Previous work has indicated that the promising PTP inhibitors may be s...

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Dettagli Bibliografici
Pubblicato in:Drug Des Devel Ther
Autori principali: Kostrzewa, Tomasz, Sahu, Kamlesh K, Gorska-Ponikowska, Magdalena, Tuszynski, Jack A, Kuban-Jankowska, Alicja
Natura: Artigo
Lingua:Inglês
Pubblicazione: Dove Medical Press 2018
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6287413/
https://ncbi.nlm.nih.gov/pubmed/30584278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S186614
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