Aurintricarboxylic acid structure modifications lead to reduction of inhibitory properties against virulence factor YopH and higher cytotoxicity

Yersinia sp. bacteria owe their viability and pathogenic virulence to the YopH factor, which is a highly active bacterial protein tyrosine phosphatase. Inhibition of YopH phosphatase results in the lack of Yersinia sp. pathogenicity. We have previously described that aurintricarboxylic acid inhibits...

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Vydáno v:World J Microbiol Biotechnol
Hlavní autoři: Kuban-Jankowska, Alicja, Sahu, Kamlesh K., Gorska, Magdalena, Niedzialkowski, Pawel, Tuszynski, Jack A., Ossowski, Tadeusz, Wozniak, Michal
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Netherlands 2016
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Original Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4999467/
https://ncbi.nlm.nih.gov/pubmed/27562597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11274-016-2123-3
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