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Synthesis of small peptide compounds, molecular docking, and inhibitory activity evaluation against phosphatases PTP1B and SHP2

BACKGROUND: The protein tyrosine phosphatases PTP1B and SHP2 are promising drug targets in treatment design for breast cancer. Searching for specific inhibitors of their activity has recently become the challenge of many studies. Previous work has indicated that the promising PTP inhibitors may be s...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Kostrzewa, Tomasz, Sahu, Kamlesh K, Gorska-Ponikowska, Magdalena, Tuszynski, Jack A, Kuban-Jankowska, Alicja
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6287413/
https://ncbi.nlm.nih.gov/pubmed/30584278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S186614
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