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Inhibitor binding mode and allosteric regulation of Na(+)-glucose symporters
Sodium-dependent glucose transporters (SGLTs) exploit sodium gradients to transport sugars across the plasma membrane. Due to their role in renal sugar reabsorption, SGLTs are targets for the treatment of type 2 diabetes. Current therapeutics are phlorizin derivatives that contain a sugar moiety bou...
Shranjeno v:
| izdano v: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group UK
2018
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6286348/ https://ncbi.nlm.nih.gov/pubmed/30532032 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07700-1 |
| Oznake: |
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