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Inhibitor binding mode and allosteric regulation of Na(+)-glucose symporters

Sodium-dependent glucose transporters (SGLTs) exploit sodium gradients to transport sugars across the plasma membrane. Due to their role in renal sugar reabsorption, SGLTs are targets for the treatment of type 2 diabetes. Current therapeutics are phlorizin derivatives that contain a sugar moiety bou...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Bisignano, Paola, Ghezzi, Chiara, Jo, Hyunil, Polizzi, Nicholas F., Althoff, Thorsten, Kalyanaraman, Chakrapani, Friemann, Rosmarie, Jacobson, Matthew P., Wright, Ernest M., Grabe, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6286348/
https://ncbi.nlm.nih.gov/pubmed/30532032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07700-1
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